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KMID : 0614720070500030274
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Journal of Korean Medical Association
2007 Volume.50 No. 3 p.274 ~ p.278
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Role of Beta-blockers in Treatment of Heart Failure
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Kim Duk-Kyung
Kim Sue-Jin
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Abstract
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Anti-adrenergic medication is very important to the treatment of chronic heart failure because a failing human heart is adrenergically activated. The increase in cardiac adrenergic drive and circulating norepinephrine are damaging to a failing heart. Certain beta-blockers have been shown to improve the cardiac function and symptoms and to reduce the risk of death and hospitalization in patients with heart failure. Recently, the third-generation beta-blockers have emerged for the treatment of heart failure. This article reviews the neurohormonal pathophysiology of heart failure and the different beta-blockers and their effects.
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KEYWORD
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Heart failure, Beta-blocker
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